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Merck Serono Announces CHMP Positive Opinion to Extend Kuvan Use to Children with PKU Below 4 Years of Age

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DARMSTADT, Germany, May 22, 2015 /PRNewswire/ —

Not intended for UK based media

CHMP recommendation based on results from the Phase IIIb SPARK study

Merck Serono, the biopharmaceutical business of Merck, today announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion on an update to the product information for its product Kuvan® (sapropterin dihydrochloride). Following review of the data from SPARK[*] , a Phase IIIb clinical study, the CHMP has recommended that the Kuvan indication is extended to allow its use in children with phenylketonuria (PKU) below 4 years of age who have shown to be responsive to such treatment.

Luciano Rossetti, Head of Global Research & Development at Merck Serono, said, “PKU is a rare disease with significant consequences – but if managed appropriately, it doesn’t have to impair child development or quality of life for children and adults. We are committed to helping patients with PKU, both at adult age and during childhood. The positive CHMP opinion is an important step towards being able to use Kuvan also in children right from diagnosis and evidence of responsiveness at birth.”

Detailed 26-week data from the SPARK study were presented at the Society for the Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium in September 2014. The SPARK study showed that the addition of Kuvan to a phenylalanine-restricted diet significantly increased phenylalanine tolerance by 30.5 mg/kg/day in children with PKU below 4 years of age and responsive to Kuvan, when compared with phenylalanine tolerance in children following a phenylalanine-restricted diet alone (p<0.001).

PKU is an inborn metabolic disorder that causes the toxic accumulation of phenylalanine, an essential amino acid contained in all protein-rich foods, in the brain and blood.[1],[2]Untreated, PKU can lead to intellectual disability, seizures and other serious medical problems.[1],[2] In many countries, implementation of national newborn screening programs has allowed identification of children with PKU at birth, enabling the management of the disease to begin as early as possible in order to prevent potentially severe neurological damage.[3] However, in Europe there is currently no licensed medication for the treatment of PKU in children who are below 4 years of age.

If approval is granted by the European Commission, the Summary of Product Characteristics (SmPC) will be updated to include details about the extended use of Kuvan in this younger population.

The original European marketing authorization for Kuvan was granted in 2008. In Europe, Kuvan was the first, and yet remains the only medication in combination with phenylalanine-restricted diet designed to reduce the concentration of phenylalanine in the blood and brain in those patients who are responsive to Kuvan to prevent the debilitating effects of PKU.[4] Kuvan is currently indicated in patients of all ages with tetrahydrobiopterin (BH4) deficiency, and in those aged 4 years and above with PKU (due to phenylalanine hydroxylase enzyme deficiency) who are responsive to Kuvan.

Kuvan is marketed by Merck Serono outside the USA, Canada and Japan, by BioMarin in the USA and Canada, and under the name Biopten® by Asubio Pharma in Japan. In the USA and Europe, Kuvan received orphan drug designation.

*SPARK: Safety Pediatric EfficAcy PhaRmacokinetic with Kuvan (sapropterin dihydrochloride)

References:

Blau N: Phenylketonuria and BH4 deficiencies. Bremen: Uni-Med; 2010
Blau N, van Spronsen FJ, Levy HL: Phenylketonuria. Lancet 2010,376:1417-1427
Loeber JG. Neonatal screening in Europe: the situation in 2004. J Inherit Metab Dis 2007;30:30-38
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000943/human_med_000880.jsp&mid=WC0b01ac058001d124, Accessed 09.04.2015

About phenylketonuria (PKU)

PKU is an autosomal recessive genetic disorder caused by a defect or a deficiency of the enzyme phenylalanine hydroxylase (PAH). PAH is required for the metabolism of phenylalanine, an essential amino acid found in all protein-containing foods. It affects approximately 1/10,000 newborns in Europe. If PKU patients are not treated with a phenylalanine-restricted diet, phenylalanine will accumulate in the blood and brain to abnormally high levels, thereby resulting in a variety of complications including clinically significant mental retardation and brain damage, mental illness, seizures and tremors, and cognitive problems. Universal systematic newborn screening programs were developed in the 1960s and early 1970s to enable diagnosis of all patients with PKU patients at birth.

About tetrahydrobiopterin (BH4) deficiency

BH4 deficiency is a very rare inborn error of metabolism, and is estimated to account for 1-2 % of cases of hyperphenylalaninemia (HPA). BH4 deficiency is an autosomal recessive genetic condition and can result from deficiencies of any of the five different enzymes involved in BH4 synthesis and regeneration. BH4 is a necessary co-factor for PAH. Therefore, BH4 deficiency impairs PAH activity leading to a biochemical situation similar to PKU, with HPA resulting from deficient conversion of phenylalanine to tyrosine. In addition, since BH4 is also a necessary co-factor for both tyrosine hydroxylase and tryptophan hydroxylase, BH4 deficiency causes deficiencies in the downstream neurotransmitter products of these amino acids including catecholamines and serotonin. Dietary limitation of whole protein or phenylalanine intake is often not necessary with BH4 treatment. However, since BH4 does not cross the blood brain barrier, concomitant therapy with neurotransmitter precursors, i.e. levodopa and 5-hydroxytryptophan, may be necessary to boost central nervous system substrate levels for catecholamine and serotonin synthesis, respectively

About Kuvan

Kuvan® (sapropterin dihydrochloride) is an oral therapy and the first treatment indicated in Europe for the treatment of hyperphenylalaninemia (HPA) due to phenylketonuria (PKU) in patients from the age of 4 years who have shown to be responsive to Kuvan, or due to tetrahydrobiopterin (BH4) deficiency. Kuvan was developed jointly by BioMarin Pharmaceutical Inc. and Merck Serono. In the US, Kuvan is marketed by BioMarin and is indicated for the treatment of HPA due to PKU without age restriction. The current EU label states that safety and efficacy of Kuvan in pediatric PKU patients less than 4 years of age have not been established in clinical studies. Kuvan is to be used in conjunction with a phenylalanine-restricted diet.

Kuvan is the synthetic form of 6R-BH4, a naturally occurring co-factor that works in conjunction with the enzyme phenylalanine hydroxylase (PAH) to metabolize phenylalanine into tyrosine. Clinical data show that Kuvan produces significant reductions in blood phenylalanine concentration in a large subset of patients.

Most common adverse reactions reported with the use of Kuvan include headache, runny nose, diarrhea, vomiting, sore throat, cough, abdominal pain, stuffy nose and low levels of phenylalanine in the blood.

Kuvan is approved in 51 countries worldwide, including member states of the European Union and the USA. Under the terms of the agreement with BioMarin, Merck Serono has exclusive rights to market Kuvan in all territories outside the USA, Canada and Japan.

About the SPARK study

SPARK is a Phase IIIb, multicenter, open-label, randomized, controlled study designed to assess the efficacy, safety, and population pharmacokinetics of Kuvan in patients younger than 4 years old with PKU who have been previously shown to be responsive to Kuvan in a response test. The study was requested by the European Medicines Agency (EMA) as a post-authorization measure and conducted under a Pediatric Investigational Plan. Patients were randomized to Kuvan (10 mg/kg/day) plus a phenylalanine-restricted diet, or to a phenylalanine-restricted diet alone, for 26 weeks. Subject to a patient's phenylalanine tolerance after approximately 4 weeks, the Kuvan dose could be increased in a single step to 20 mg/kg/day.

The primary endpoint of the study was to compare phenylalanine tolerance achieved in both arms after 26 weeks of treatment. The group of patients receiving Kuvan had an adjusted mean phenylalanine tolerance of 80.6 mg/kg/day at the end of 26 weeks of treatment compared with that of 50.1 mg/kg/day in the group of patients receiving diet alone (∆ 30.5 mg/kg/day). The mean phenylalanine tolerance in the group receiving Kuvan in addition to a phenylalanine-restricted diet (n=27) increased from a baseline of 37.1°mg/kg/day (standard deviation [SD] 17.3 mg/kg/day) to 80.6 mg/kg/day (SD 4.2 mg/kg/day) after 26 weeks. In the group following a phenylalanine-restricted diet alone (n=29), the increase was from 35.8 mg/kg/day (SD 20.9 mg/kg/day) to 50.1 mg/kg/day (SD 4.3 mg/kg/day).

Secondary study endpoints included change in levels of blood phenylalanine during the study period, change in dietary phenylalanine tolerance over time (from baseline to 26 weeks) in both groups, as well as assessment of neurodevelopmental function, growth parameters and safety.

The safety profile of Kuvan in this population was consistent with the safety profile of Kuvan described in the European Summary of Product Characteristics, which lists the most common adverse reactions reported with the use of Kuvan, including headache, runny nose, diarrhea, vomiting, sore throat, cough, abdominal pain, stuffy nose and low levels of phenylalanine in the blood. The most frequent Kuvan-related adverse reactions in the SPARK trial were reported as "amino acid level decreased" (hypophenylalaninemia), rhinitis and vomiting. The long-term efficacy and safety of Kuvan are being assessed in the ongoing study's 3-year extension period, in which all patients are offered to receive Kuvan in addition to the phenylalanine-restricted diet.

About Merck Serono

Merck Serono is the biopharmaceutical business of Merck. With headquarters in Darmstadt, Germany, Merck Serono offers leading brands in 150 countries to help patients with cancer, multiple sclerosis, infertility, endocrine and metabolic disorders as well as cardiovascular diseases. In the United States and Canada, EMD Serono operates as a separately incorporated subsidiary of Merck Serono.
Merck Serono discovers, develops, manufactures and markets prescription medicines of both chemical and biological origin in specialist indications. We have an enduring commitment to deliver novel therapies in our core focus areas of neurology, oncology, immuno-oncology and immunology.
For more information, please visit http://www.merckserono.com.

All Merck Press Releases are distributed by e-mail at the same time they become available on the Merck Website. Please go to http://www.merckgroup.com/subscribe to register online, change your selection or discontinue this service.

Merck is a leading company for innovative and top-quality high-tech products in healthcare, life science and performance materials. The company has six businesses – Merck Serono, Consumer Health, Allergopharma, Biosimilars, Merck Millipore and Performance Materials – and generated sales of around € 11.3 billion in 2014. Around 39,000 Merck employees work in 66 countries to improve the quality of life for patients, to foster the success of customers and to help meet global challenges. Merck is the world's oldest pharmaceutical and chemical company – since 1668, the company has stood for innovation, business success and responsible entrepreneurship. Holding an approximately 70% interest, the founding family remains the majority owner of the company to this day. Merck, Darmstadt, Germany, holds the global rights to the Merck name and brand. The only exceptions are Canada and the United States, where the company operates as EMD Serono, EMD Millipore and EMD Performance Materials.
Source: Merck Serono

Written by asiafreshnews

May 26, 2015 at 10:01 pm

Posted in Uncategorized

EXPO Solar 2015, the Most Preferred PV Business Platform in Asia, will be held from September 9-11 in Korea

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— A large number of buyers from over 20 countries will attend the expo as the size of the Asian PV market has grown

SEOUL, South Korea /PRNewswire/ — The International Solar Energy Expo & Conference (EXPO Solar www.exposolar.org), the largest solar energy exhibition in Asia in the 2nd half of 2015, will be held at KINTEX in Korea for 3 days from September 9 (Wed.) to September 11 (Fri.).

More than 320 companies from over 20 countries, including China, Europe, Japan, the Middle East and the U.S. will participate in the ‘EXPO Solar 2015’ (www.exposolar.org), which celebrates its 7th anniversary this year. Over 28,000 foreign and Korean buyers and visitors will attend the expo.

Last year global PV manufacturers, including Canadian Solar, JSPV and DAQO Solar, global PV production equipment suppliers like Schmid, ASYS Group and DKSH, and PV installation and construction companies like Top Solar and S-PV exhibited various products and solutions to EXPO Solar 2014 which has established itself as the preferred PV business exhibition in Asia, resulting in products and solutions worth a total of $850 millionbeing sold through meetings with buyers.

Meanwhile, the industry is expected to recover during 2015 as the PV inventory glut will be alleviated. Also, the PR period for this year’s expo has been extended because applications were accepted very early on, and exhibitors are eagerly anticipating a wealth of benefits, such as opportunities to attend buyer meetings. As a result, the number of new applications and companies that will reinforce their presence at this year’s expo has noticeably increased compared to last year.

In addition, over 30 experts from the US, Germany, China and Japan as well as Korea will be presenting at the ‘PV World Forum,’ an international PV conference that will be held concurrently.

About EXPO Solar

EXPO Solar 2015 (www.exposolar.org) is the preferred destination for companies looking to increase their presence and expand their business in Asia thanks to the participation of diverse solar players from key Asian countries and its location based in Korea.

EXPO Solar 2015 will be held September 9-11, 2015, at the Korea International Exhibition Center (KINTEX),Seoul, Korea.

For more information on EXPO Solar 2015, please visit www.exposolar.org

Source: EXPO Solar 2015 Exhibition Bureau
Related Links:

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May 26, 2015 at 7:04 pm

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Vistra Group to be acquired by Baring Private Equity Asia

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— Acquisition to accelerate Group’s strategy for growth through market consolidation
— Vistra quadrupled in size under ownership of IK Investment Partners
— Completion subject to regulatory approvals

HONG KONG /PRNewswire/ — Vistra Group (the “Group” or “Company”), one of the world’s leading providers of company formations, trust, corporate and fund administration services, today announced its majority shareholders, IK Investment Partners through its IK 2007 Fund, and Vistra Group management, have reached an agreement whereby Baring Private Equity Asia (“Baring Asia”) will acquire a majority stake in Vistra Group. The Vistra Group management team will continue to hold a significant shareholding in the Company after completion. The completion of the transaction is subject to regulatory approvals. The parties have agreed not to disclose the financial terms of the transaction.

Baring Asia is one of the largest and most established independent private equity firms in Asia and advises funds that manage more than USD9 billion in committed capital. The firm runs a panAsian investment program, sponsoring management buyouts and providing growth capital to companies for expansion or acquisitions.

Commenting on the acquisition, Martin Crawford, CEO of Vistra Group, said, “Partnering with Baring Asia is an exciting step for Vistra Group. With Baring Asia’s support we will be able to further enhance our leading position in a consolidating industry. We are delighted that Baring Asia has demonstrated a strong commitment to the growth of Vistra’s business as well as to our exceptional people who have been instrumental to our success.”

“With IK Investment Partners’ help we have built Vistra Group into one of the top four corporate trust service providers globally and the number one in Asia, and I would like to thank them for their contribution and commitment over the past six years,” Mr Crawford added.

Jean Eric Salata, Founder and CEO of Baring Asia, added, “Vistra has a winning management team running a solid business with great potential. We look forward to helping management achieve its vision of continuing to grow Vistra as a global market leader.”

Remko Hilhorst, Partner of IK Investment Partners, added, “We are privileged to have been a part of Vistra’s strong success over the past six years. Vistra quadrupled in size under our ownership and became a global leader in its field. Together with the leadership team, we have accomplished our goal of creating value through organic growth and a number of strategic acquisitions in several high growth geographies such as Asia and Central and Eastern Europe. Vistra Group has a very exciting future ahead, and we wish the business continued success going forward.”

JP Morgan, Morgan Stanley and Lazard acted as financial advisors and Clifford Chance as legal advisor to the Company and IK Investment Partners; Goldman Sachs, Credit Suisse and Linklaters advised Baring Private Equity Asia.

For further information, please contact:

Vistra Group
Joanna Donne, Brunswick Group
Email:
Media.Enquiries@vistra.com
Telephone: +852 9221 3930

Baring Private Equity Asia
Richard Barton, Newgate Communications
Email: Richard.barton@newgate.asia
Telephone: +852 9301 2056

IK Investment Partners
Charlotte Laveson Girard
Email: charlotte.laveson@ikinvest.com
Telephone: +44 207 304 7136

About Vistra Group

Ranked among the top four corporate service providers globally, Vistra Group is a versatile group of professionals, providing a uniquely broad range of services and solutions. Our capabilities span across company formations to trust, fiduciary and fund administration services. Comprising two key brands, Vistra and OIL, the Group employs over 1,300 employees in 46 offices across 35 jurisdictions.

For more information, please visit: www.vistragroup.com, www.vistra.com and www.oilglobal.com

About Baring Private Equity Asia

Baring Private Equity Asia is one of the largest and most established independent private equity firms in Asia and advises funds that manage more than USD9 billion in committed capital. The firm runs a panAsian investment program, sponsoring management buyouts and providing growth capital to companies for expansion or acquisitions.

The firm has been investing in Asia since its formation in 1997 and has over 110 employees located across seven offices in Hong Kong, Shanghai, Beijing, Mumbai, Singapore, Jakarta and Tokyo. Baring Asia currently has over 30 portfolio companies across Asia with a total of 95,000 employees and sales of approximately USD30 billion in 2014.

For more information, please visit: www.bpeasia.com

About IK Investment Partners

IK Investment Partners (“IK”) is a Pan-European private equity firm focused on investments in Europe. Since 1989, IK Funds have raised more than Euro 7 billion of capital and invested in close to 90 European companies. IK Funds invest together with management teams in mid-sized companies that have strong improvement potential, operating in the business services, care, industrial goods and consumer goods sectors. The current portfolio comprises 21 companies.

For more information, please visit: www.ikinvest.com

Source: Vistra Group

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May 26, 2015 at 6:43 pm

Posted in Uncategorized

Content Increasingly Contextual: Marketers Need to Account for Device, Platform, Location and Sector When Hunting ROI

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-Waggener Edstrom Launches the Second Edition of Their Asia-Pacific Study on the Business Impact of Content Marketing

SINGAPORE /PRNewswire/ — Leading independent integrated communications agency Waggener Edstrom Communications (WE) has released the second edition of its proprietary Asia-Pacificresearch study, Content Matters: The Impact of Brand Storytelling Online in 2015.

Photo – http://photos.prnewswire.com/prnh/20150522/218033-INFO

This year’s report explores the correlation between devices and social media platforms as it relates to purchase behavior, revealing the factors that drive consumer brand advocacy and how those dynamics vary across industry and geography in Asia-Pacific.

The 2015 study surveyed over 4,000 consumers in nine markets across Asia-Pacific, including Australia,mainland China, India, Indonesia, Hong Kong, Malaysia, Philippines, Singapore and South Korea. It also covered nine industries, including Beauty, Consumer Electronics, Finance & Banking, Food & Beverage, Healthcare, Mobile Devices & Tablets, Personal Care, Restaurants & Dining, and Travel & Tourism.

“Riding on the success of the first Content Matters report, we wanted to take a deeper dive into what consumers really think in relation to brands online, and the research provided some fascinating facts,” said Henry Wood, APAC Lead, WE Studio D. “Simply put, we learned that content is never a sole panacea. Effective content is a cocktail of geography, platform, industry and device. In order to stay ahead of the curve marketers must have data-driven insights that help prioritize their investments and capture value.”

  • It’s all about the ecosystem
    The data show that consumers want cross-channel experiences, via an ecosystem of online and offline touch points. However, the dominant platforms shift according to industry and geography. In South Korea, for example, regardless of industry, blogs dominate purchasing decisions; in the Philippines, social media carries the greatest purchase influence. And in the majority APAC markets, corporate websites are key for Finance & Banking decisions, while Restaurant & Dining purchases rely most heavily on word of mouth.
  • Content is a local game
    Although Facebook and WhatsApp currently dominate the region, the third most preferred social network is different in almost every market. Singapore consumers are hot for Instagram, Indonesians love to tweet, andmainland China is bonding via WeChat. Furthermore, willingness to engage with brands and motivation is market-led. For example, access to discounts is the key reason consumers follow a brand in Hong Kong(46%) and Indonesia (38%); in mainland China, it’s simple love for the brand; in India, it’s because consumers find the content inspirational. What this means for campaign design is Southeast Asia should be promotion-led, while marketers will need to focus on brand in mainland China and charm in India.
  • Multiple devices matter
    The data indicate that consumers are using multiple screens to engage with brands and gather information prior to purchase, pivoting between two devices, typically a smartphone and a computer. Additionally, not only are they amalgamating branded content before taking action, but they do so in different ways depending on their location.

“As an integrated communications agency, we are committed to making sure everything we do maps to business needs and is backed by data. Using our own internal insights and analytics tools and experts, we’re able to conduct APAC-level research to ascertain what drives consumer interests when it comes to brand advocacy, and use this data to help our clients create more impactful content that links to commercial outcomes,” said Matthew Lackie, Senior Vice President, Asia Pacific, Waggener Edstrom.

Download the report: http://apac.waggeneredstrom.com/what-we-do/digital-influence-insights/content-matters/.

Waggener Edstrom Communications (WE) is a global independent communications agency. To learn more, visithttp://www.WaggenerEdstrom.com

Source: Waggener Edstrom Communications

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May 26, 2015 at 5:29 pm

Posted in Uncategorized

First Ethernet-Compliant Laser Safety Scanners, Now Available at RS Components

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-Omron OS32C family allows configuration, status monitoring, and alert analysis from the desktop

BEIJING /PRNewswire/ — RS Components (RS), the trading brand ofElectrocomponents plc (LSE:ECM), the global distributor for engineers, has added an industry first to its machine guarding and safety portfolio: Ethernet-compliant laser scanners that dramatically simplify management of safety zones on factory floors.

First Ethernet-compliant laser safety scanners, now available at RS Components
First Ethernet-compliant laser safety scanners, now available at RS Components

The Omron OS32C type 3 safety laser scanners provide compact and versatile presence detection to protect machine operators and factory staff. By integrating an Ethernet interface, the scanners allow easy configuration via a remote PC with few inputs required. Supervisors can monitor status from the desktop and analyse the causes of any emergency stops, which helps improve safety practices and reporting. Multiple OS32Cs can be connected to the LAN and monitored in turn.

Each sensor allows one safety zone of up to 4 metres radius and two warning zones of up to 15 metres, and can generate an alarm sounder, speed-control signal or emergency stop if zone conditions are breached. It is also capable of direction monitoring, and can detect intrusion from either side thanks to the generous 270degreedetection angle.

The OS32C comprises a detachable sensor block and an I/O block, which stores the configuration. This allows fast and easy replacement of any damaged sensors, with no reprogramming required. The I/O block is available with rear or side cable entry for extra flexibility. At 104.5mm diameter, weighing 1.3kg, and drawing only 5W active and 3.75W standby power consumption, the sensors are easy both to handle and install. RS also has cables and brackets to assist installers.

About RS Components

RS Components and Allied Electronics are the trading brands of Electrocomponents plc, the global distributor for engineers. With operations in 32 countries, we offer around 500,000 products through the internet, catalogues and at trade counters to over one million customers, shipping more than 44,000 parcels a day. Our products, sourced from 2,500 leading suppliers, include semiconductors, interconnect, passives and electromechanical, automation and control, electrical, test and measurement, tools and consumables.

Electrocomponents is listed on the London Stock Exchange and in the last financial year ended 31 March 2014had revenues of GBP1.27bn.

For more information, please visit the website at http://china.rs-online.com .

RS Components
Tan Soo Chun
Public Relations Manager – Asia Pacific
Email: soochun.tan@rs-components.com
Telephone: +65-6391-5745

Edelman Public Relations (Singapore)
Yvette Yeo
Manager
Email: yvette.yeo@edelman.com
Telephone: +65-6347-2355

Further information is available via these links:

@RSElectronics; @alliedelec; @designsparkRS

RS Components on Linkedin
http://www.linkedin.com/company/rs-components

RS Components on Weibo
http://e.weibo.com/u/3206377000?type=0

Relevant Links:

Electrocomponents plc
www.electrocomponents.com

RS Components
www.rs-online.com/

DesignSpark
www.designspark.com

Photo – http://photos.prnasia.com/prnh/20150504/8521502675
Logo – http://www.prnasia.com/sa/2011/05/04/20110504368830.jpg

Source: RS Components Singapore

Related stocks: LSE:ECM OTC-PINK:EENEY

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May 26, 2015 at 4:11 pm

Posted in Uncategorized

New Simpleview CMS Launches as SaaS Platform

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TUCSON, Ariz. /PRNewswire/ — With 13 websites complete and over 50 more in production, the new Simpleview CMS is establishing itself as the content management standard for destination marketing organizations (DMOs) across the globe. The reimagined Software as a Service (SaaS) platform was built with one goal in mind: to give everyday users the ability do to anything they need to do and developers the ability to do anything they want to do.

Simpleview CMS
Simpleview CMS

Photo – http://photos.prnewswire.com/prnh/20150520/217643-INFO

Simpleview CMS launches with over 45 industry-leading web modules built specifically for DMOs on a new open source technology stack. The redesigned user interface includes a multitude of new features, including drag and drop functionality, real time page editing feedback for responsive desktop, tablet and mobile interfaces, an on demand support knowledgebase with video tutorials, dashboard analytics and more. Not only that, the platform is amply equipped for international organizations. The CMS supports countless languages and even a powerful content delivery network (CDN), which disperses assets worldwide and promotes lightning-fast page downloads for global visitors.

“The conversion to SaaS for Simpleview CMS was a tremendous undertaking,” states Eric Rankin, CMS Product Manager at Simpleview. “Software as a Service has become a technology standard across the board at Simpleview and in most industries. Our Product and R&D team was assembled to monitor emerging trends that add value to our clients and partners, and the result is an unparalleled content management capability tailored specifically for each DMO and its budget.”

A major draw to the new CMS has been its shift to a licensed model. This plan provides a lower up-front cost with an annual fee, enabling long-term budgeting ease and protection against the rapid pace of technology change. This especially allows for tremendous flexibility with future rebrands, reskins and redesigns, ensuring DMOs only incur design costs as their marketing message evolves.

The latest iteration of CMS is part of an array of destination marketing products, and is a fully integrated solution capable of pulling from and feeding data into Simpleview CRM, state and national aggregation, platforms, destination dashboards and more. For more information, visit www.simpleviewinc.com/cms.

About Simpleview
Simpleview is the industry’s leading provider of CRM, CMS, website design, search marketing, revenue generation, and mobile technologies to destination marketing organizations (DMOs). Simpleview employs 175+ people and represents 375+ DMOs in North America and beyond.

CONTACT: Cara Frank, Director of Marketing, +1.520.575.1151, cfrank@simpleviewinc.com,www.simpleviewinc.com

Photo – http://photos.prnasia.com/prnh/20150522/8521503328

Source: Simpleview

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May 26, 2015 at 2:20 pm

Posted in Uncategorized

9 Book Promotion Tips that Lead to More Sales

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NEW YORK /PRNewswire/ — The process of writing and publishing a book can be likened to that of a relay race: the first leg is spent researching and writing your book – which can take months if not years to complete – and the last leg – one that can be the most tiring as you approach the home stretch – is the promotional strategy you put in place in order to sell more books.

Logo – http://photos.prnewswire.com/prnh/20110831/NY59180LOGO

Penny C. Sansevieri, CEO and founder of Author Marketing Experts, Inc. understands that books don’t sell themselves and in her latest article posted to PR Newswire’s Small Business PR Toolkit, Sansevieri provides nine tips to propel your book sales to the next level.

  1. Don’t set it and forget it. Your marketing approach should be monitored and adapted as necessary. Stay up to date with what is happening in the current marketplace by either attending conferences or reading industry news/blogs. Look for successful trends to uncover.
  2. Newsletters. These can go a long way in educating and persuading your audience to come back for more. Develop a program that provides value and engagement all the while maintaining the integrity of your brand.
  3. Giveaways. Think outside of the box when attempting to entice your readers. Consider a monthly drawing for a gift card or other items that your audience can only find through you.
  4. Audio books. If you’re looking to expand audience reach it would do well to embrace additional publishing formats. Don’t overlook this rising market that has other authors all abuzz.

To read Sansevieri’s five other book promotion secrets, read her article here: http://bit.ly/1FzK3Gy.

PR Newswire’s Small Business PR Toolkit is a comprehensive resource that provides small businesses and entrepreneurs the tools to develop an affordable public relations and marketing plan that helps generate interest from potential customers, engage with key audiences and grow their businesses. The toolkit features relevant content such as informative white papers, interactive webinars and how-to articles and premium access to educational resources, as well as the opportunity to take advantage of special offers designed specifically for small businesses. To request information on how PR Newswire can help your small business, click here. You can receive updates on new Small Business PR Toolkit content by following @prnsmallbiz on Twitter.

About PR Newswire
PR Newswire (www.prnewswire.com) is the premier global provider of multimedia platforms that enable marketers, corporate communicators, sustainability officers, public affairs and investor relations officers to leverage content to engage with all their key audiences. Having pioneered the commercial news distribution industry over 60 years ago, PR Newswire today provides end-to-end solutions to produce, optimize and target content — from rich media to online video to multimedia — and then distribute content and measure results across traditional, digital, mobile and social channels. Combining the world’s largest multi-channel, multi-cultural content distribution and optimization network with comprehensive workflow tools and platforms, PR Newswire enables the world’s enterprises to engage opportunity everywhere it exists. PR Newswire serves tens of thousands of clients from offices in the Americas, Europe, Middle East, Africa and the Asia-Pacific region, and is a UBM plc company.

Contact:
Amanda Eldridge
Director, Strategic Channels
+1 201-360-6906
Amanda.eldridge@prnewswire.com

Source: PR Newswire Association LLC

Related stocks: LSE:UBM OTC-PINK:UBMPY

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May 26, 2015 at 2:17 pm

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Designer Parfums and LUXE Brands to purchase Frederic Fekkai’s salons and leading hair care brand from Procter & Gamble

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– Designer Parfums and LUXE Brands have formed a joint venture, Fekkai Brands, LLC, to acquire the business

NEW YORK, May 21, 2015 /PRNewswire/ — Designer Parfums CEO Dilesh Mehta and Tony Bajaj, Founder and CEO of LUXE Brands, have collaborated to form a joint venture to acquire the Frederic Fekkai luxury hair care brand and salons from Procter & Gamble, effective June 30, 2015. This newly formed entity is called Fekkai Brands, LLC. The Fekkai product line is distributed in some of the finest beauty retailers as well as in Fekkai’s namesake salons. Frederic Fekkai, its founder, is the leader in luxury hair care. Mr. Fekkai retains his role as adviser and Brand architect at the flagship salon on 5th Avenue in New York.

The Fekkai business comprises a range of award-winning hair products and seven salons in New York, Connecticut, Florida, Texas and California. Approximately 225 people are currently employed in the salon business; they are expected to transfer to the newly formed entity.

“We are excited to be working with the extraordinary talent of Frederic Fekkai and the Fekkai brand to optimize and further develop his brand of world class and innovative hair care products,” said Dilesh Mehta. Added Tony Bajaj: “This latest addition to our portfolio expands upon our vision to extend into every area of beauty; we cannot imagine a more perfect partner than Frederic Fekkai, the premier brand in hair care and salons.”

The Fekkai acquisition marks the latest exciting step in expanding ever-growing and diversified portfolio, which includes the widely anticipated Ariana Grande fragrance, set to launch in September 2015, the legendary House of Jean Patou fragrances, including the iconic JOY, and DDF, the well-known dermatologic skincare brand.

About Frederic Fekkai & Co.

Frederic Fekkai & Co. is the leader in luxury hair care, offering a complete range of innovative products and exclusive, full-service salons. Fekkai products are distributed through the finest beauty retailers around the world and Frederic Fekkai Salons.

About Designer Parfums

Designer Parfums is a family-owned, entrepreneurial business and has established itself as a creative and innovative force in the world of fine fragrance and beauty. Their current portfolio of brands are wholly owned or operated under license – investing in both fashion and beauty, it contains a broad spectrum of designer and lifestyle brands, including the renowned House of JEAN PATOU. Designer Parfums plans to expand its portfolio of brands through brand ownership, license and distribution agreements in order to cover all major markets.

About LUXE Brands

LUXE Brands is a prestige beauty company with a portfolio of brands distributed in over 70 countries. It was founded with the mission to develop world-class brands that will endure. The company plans to continue to expand its diverse brand portfolio and establish a solid foundation in the beauty industry. In September 2015, LUXE will launch the highly anticipated Ariana Grande fragrance. The company has also added DDF to its portfolio, a top dermatologic skincare brand.
Source: LUXE Brands

Written by asiafreshnews

May 26, 2015 at 1:34 pm

Posted in Uncategorized

Hong Kong’s First Bundling of 4K Home Broadband with Entertainment Content by HGC and Letv Triumphs in the Global Telecoms Business Innovation Awards

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HONG KONG/PRNewswire/ — Hong Kong’s first bundling of 4K home broadband with entertainment, based on an innovative OTT (over-the-top) partnership model, has won a “Consumer Service Innovation Award” in the ninth Global Telecoms Business Innovation Awards.

Hong Kong's first bundling of 4K home broadband with entertainment content by Hutchison Global Communications Limited (HGC) and Letv has won a "Consumer Service Innovation Award" in the ninth Global Telecoms Business Innovation Awards. Sierra Ma (left), General Manager, International Business Development of Letv, and Oyovwe Okorodudu (right), Assistant Vice President, EMEA of Hutchison Global Communications Limited receive the honour on behalf of Letv and HGC.
Hong Kong’s first bundling of 4K home broadband with entertainment content by Hutchison Global Communications Limited (HGC) and Letv has won a “Consumer Service Innovation Award” in the ninth Global Telecoms Business Innovation Awards. Sierra Ma (left), General Manager, International Business Development of Letv, and Oyovwe Okorodudu (right), Assistant Vice President, EMEA of Hutchison Global Communications Limited receive the honour on behalf of Letv and HGC.

The winning package comprises content from Letv — the world’s first video website and Internet video company to launch an IPO — and superior broadband service delivered by Hutchison Global Communications Limited (HGC), a leading international fixed-line telecoms operator.

Run by the Global Telecoms Business magazine, the Global Telecoms Business Innovation Awards scheme recognises and rewards innovation and excellence throughout the international telecoms industry.

After identifying huge consumer demand for online videos, Letv decided to collaborate with HGC’s 3Home broadband to launch Hong Kong’s first bundling of 4K home broadband and entertainment content.

A dedicated Letv broadband channel enables 3Home Broadband users to stream or download Letv’s 4K ultra-HD videos, so they can enjoy a smoother and faster home entertainment experience. The bundle plan enables HGC to attract new customers seeking online video services, then delight them by going the extra mile to provide a high-definition entertainment experience. This strategic collaboration with HGC demonstrates Letv’s vision for OTT industry development and enhances the company’s ecosystem, while opening up opportunities for a greater share of the international market.

HGC has become well known in industry circles for co-operating with OTT content providers and serving their needs. Last year, for example, HGC provided Letv with data centre hosting and colocation facilities, as well as international and local networking, plus customer and marketing services.

Letv’s localised video content and smart devices then became part of Hong Kong’s first bundled offer comprising 4K home broadband service and entertainment programming. HGC’s extensive fibre-optic local network and abundance of bandwidth enable HGC to identify and prioritise Letv’s 4K ultra-HD content during transmission.

What’s more, the fact that this 4K content is stored in HGC’s world-class data centres means latency — or delay in transmission — is absolutely minimal, ensuring a superb 4K TV picture. In fact, HGC’s Application and Content Provider Solution has been helping world-renowned OTT service operators to expand their business footprints.

Global Telecoms Business Editor Alan Burkitt-Gray, one of the awards scheme’s judges, said: “The telecoms industry is increasingly looking to deal with content providers and content services to increase the quality of their offer to customers. This project between HGC and Letv is an imaginative collaboration between innovative companies to offer ultra-high definition entertainment services in the home, with excellent quality of performance.”

Tin Mok, Vice President & Executive Director, Asia Pacific, Letv Holdings (Beijing) Co Ltd, said: “Our co-operation with HGC is a milestone development for us because it enriches the Internet video content experience enjoyed byHong Kong people, while giving rise to a new win-win collaboration model between telecoms operators and OTT companies. This serves as a breakthrough when compared with the traditional market business model. Our success in the GTB Awards represents recognition and endorsement of Letv’s new collaborative model. We have been devoted to creating an Letv ecosystem as an Internet engine vertically-integrated to offer an online platform complete with content, terminals and applications. This collaboration leads the market and serves as an industry role model, taking such a mode of operation and user experience to a new level”

Jennifer Tan, Chief Operating Officer of Hutchison Telecommunications Hong Kong Holdings Limited, said: “We are delighted to win this award alongside Letv because it demonstrates market and industry recognition of our innovative 4K home broadband and entertainment bundle. HGC’s comprehensive optic-fibre network synergises with Letv’s HD video programming to offer customers a fresh entertainment experience, while facilitating development of high-quality 4K TV entertainment.”

She added: “As well as providing network services, HGC has earned a glowing reputation for offering superior value-added services and one-stop solutions. We will continue to lead market development — and keep up to speed with ever-rising customer demand — by focusing on innovation.”

About Hutchison Global Communications Limited

Hutchison Global Communications Limited (HGC) owns one of the largest fibre-to-the-building telecommunications networks in Hong Kong. Since establishment in 1995, it has been fully committed to building its own optical-fibre network infrastructure and introducing advanced facilities. Coupled with its four cross-border routes integrated with all three of mainland China’s tier-one telecommunications operators and world-class international network, HGC provides a comprehensive range of fixed-line telecommunications services locally and overseas. HGC is a subsidiary of Hutchison Telecommunications Hong Kong Holdings Limited (HTHKH, Stock Code: 215). HTHKH is a leading integrated telecommunications service operator, offering mobile and fixed-line services to local and international customers. For more information on HGC, please visit www.hgc.com.hk. For more information on HTHKH, please visit www.hthkh.com.

About Letv

Founded in November 2004 by Jia Yueting, Letv Group is committed to creating the “Letv Ecosystem,” a next-generation Internet engine that is vertically-integrated to offer an online platform completed with content, terminals and applications. The Group is engaged in a rich array of businesses, spanning from Internet TV, video production and distribution, smart gadgets and large-screen applications to e-commerce, eco-agriculture and Internet-linked super-electric cars, which were launched in late 2014. The Group comprises a number of subsidiaries, including Letv.com, Leshi Zhi Xin, Le Vision Pictures, Wangjiu.com, Letv Holding, Letv Investment Management and Le Mobile. In 2014, the aggregate sales of the Group amounted to approximately RMB 10 billion.

Letv.com made history on August 12, 2010 when it was listed on the Shenzhen Stock Exchange, making it the world’s first IPO Company in the sector. Letv.com was also the first video company listed on China’s A-share market. As of March 24, 2015, the market value of Letv amounted to RMB 84 billion. Prolific as well as successful, Letv.com currently offers more than 100,000 episodes of TV dramas and over 5,000 movie titles. In addition, the site draws an estimated 250 million page views per day, 350 million users per month, 100 million daily content viewers on mobile devices, and 10 million daily content viewers on large-screen TVs.

Letv Hong Kong, as the headquarters of Asia Pacific region, was officially set up in August 2014, marking an important milestone of the company’s expansion in the overseas market. The company provides Hong Kong with an established vertically integrated ecosystem of “Platform + Content + Terminal + Application”. Letv has teamed up with 3 Home Broadband, subsidiary of Hutchison Telecommunications Hong Kong Holdings Limited, allowing customers to enjoy the best home entertainment experience with high speed broadband connectivity. As of March 2015, Letv has held 10 online flash sales in Hong Kong, with 1,000 smart TVs sold in less than 10 minutes on every occasion. Currently, Letv Hong Kong offers various sales channels for potential smart TVs customers to accommodate massive demands, including online pre-ordering services and 50+ offline outlets in Hong Kongand Macau. As the only entertainment platform with over 800 hours of 4K programmes in Hong Kong, Letv has always been committed to providing rich and diverse online content including movies, dramas, variety shows and concerts to its fans.

For more Letv information, please visit:

Letv website: http://www.letv.com
Lemall in Hong Kong: hk.shop.letv.com
Letv Facebook: http://www.facebook.com/letv.hk

Photo – http://photos.prnasia.com/prnh/20150520/8521503273

Source: Letv
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Written by asiafreshnews

May 26, 2015 at 1:00 pm

Posted in Uncategorized

Huawei Gears Up to Partner with Government in Smart Country Initiative; Announces Solutions at ICT Roadshow

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KUALA LUMPUR, Malaysia /PRNewswire/ — Several government and industry experts and new announcements to accelerate Malaysia’s Smart Country initiative formed part of the opening ceremony of the second Huawei ICT Roadshow at a city hotel on 19 June 2015.

Communications and Multimedia Minister Datuk Seri Ahmad Shabery Cheek, Mr. Wu Zhengping, Economic and Commercial Counselor, Embassy of China in Malaysia attend Roadshow; Discuss Malaysia-China trade and technology ties and potential of ICT in Smart Country aspirations
Communications and Multimedia Minister Datuk Seri Ahmad Shabery Cheek, Mr. Wu Zhengping, Economic and Commercial Counselor, Embassy of China in Malaysia attend Roadshow; Discuss Malaysia-China trade and technology ties and potential of ICT in Smart Country aspirations

The Roadshow, a platform by Huawei for industry experts to exchange ideas and discuss the positive impacts of connectivity on Malaysia, was inaugurated by Communications and Multimedia Minister Datuk Seri Ahmad Shabery Cheek. Also in attendance was Mr. Wu Zhengping, the Economic and Commercial Counselor at the Embassy of People’s Republic China in Malaysia.

As the Guest of Honor, Datuk Seri Ahmad Shabery Cheek opened the keynotes where he put forward his vision for Malaysia to transform into a Smart Country. He said, “I am delighted to be among the nation’s ICT experts and policy makers at the Huawei’s ICT Roadshow 2015. We want to use today’s platform to get the ecosystem to start thinking about the way ahead in using technology for a Smart Malaysia with the end goal of complementing and enabling all other nation building initiatives. By building on Smart Economy, Smart Environment, Smart Governance, Smart Mobility, Smart Living and Smart People, we are already infusing ICT into all spheres of the society, and in doing so, accelerating Malaysia towards a developed and modern country and enriching the lives of the rakyat.

He added, “As a global ICT leader, Huawei has the technology know-how and experience in the development of smart country initiatives. I hope that in the near future, more experts from across the ecosystem join the partnership we have formed with Huawei to jointly build a Smart Country. Let’s work together towards a common vision, and overcome challenges we face along the way. In that aspect, we welcome constructive dialogue with industry players, agencies and technology partners.”

Huawei Malaysia CEO Mr Abraham Liu said in his keynote that with its strong focus on digital inclusion, Malaysiahas the potential to be a bellwether in sustainable Smart Country initiatives in the ASEAN region. He said, “Digital connectivity and inclusion across urban and rural centers, genders, and economic strata enables countries to attract investment by providing access to skill development and employment opportunities and promoting sustainability. Innovative ICT infrastructure is fundamental to the digital restructuring of industries and the long-term development of a Better Connected Smart Country. I want to take this opportunity to announce that Huawei is committed to partner in Malaysia’s endeavor to be a Better Connected, Smart Country.”

As part of its commitment to a Better Connected Malaysia, Huawei also announced the availability of its Smart City solution in Malaysia. Together with industry partners, Huawei’s Smart City Solution offers cutting-edge end-to-end security with ubiquitous network access, a convergent command center, video surveillance cloud, and mobile policing. It provides comprehensive on-site information with visual command, cross-regional resource SHARING, and intelligent analysis functions for 360-degree security protection.

Speaking on the solution, Mr Liu said, “Cities today need effective public safety solutions for incident prevention, emergency response, and evidence collection that address these challenges. As Malaysia gears up towards its Smart Country vision, it has vast potential to leverage technology for public services and safety of its citizens. Today’s launch is a first among many pillars of our commitment to bring world class connectivity and technology to empower Malaysians.”

During this 2-day Roadshow that began today, Huawei is showcasing solutions and technologies from its three distinct business groups, all of which singularly aim at making connectivity possible for all Malaysians  at work and at home, in urban centers and beyond.

“We have received tremendous response to the event. We are excited about the potential for engaging dialogue and meaningful, long-term partnerships such a response promises. Once again, we thank the Malaysian Government, businesses, and citizens for their ongoing partnership and support!” Mr Liu concluded.

For more information, please log on to http://huaweiapac.mediaroom.com/.

About Huawei:

Huawei is a leading global information and communications technology (ICT) solutions provider with the vision to enrich life through communication. Driven by customer-centric innovation and open partnerships, Huawei has established an end-to-end ICT solutions portfolio that gives customers competitive advantages in telecom and enterprise networks, devices and cloud computing. Huawei’s 170,000 employees worldwide are committed to creating maximum value for telecom operators, enterprises and consumers. Our innovative ICT solutions, products and services have been deployed in over 170 countries and regions, serving more than one third of the world’s population. Founded in 1987, Huawei is a private company fully owned by its employees.

For more information, please visit Huawei online: www.huawei.com or follow us on:
https://www.facebook.com/HuaweiEnterpriseAPAC
https://twitter.com/HuaweiEntAPAC
http://www.youtube.com/HuaweiAPAC

Photo – http://photos.prnasia.com/prnh/20150522/8521503338

Source: Huawei
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Written by asiafreshnews

May 26, 2015 at 12:46 pm

Posted in Uncategorized